In clinical practice, thanks to this innovative technology, an electrolyzed ophthalmic spray based on pure, stable, pH-neutral HOCl (Ocudox™, marketed in Italy by Alfa Intes hereafter termed HOCl ophthalmic spray) can be used as an antiseptic with high disinfecting power. 13 Through the use of this technology, the development of highly stable (up to 2 years or more) and safe HOCl solutions was achieved and used for the development of commercial pharmaceutical formulations. 12 The stable HOCl formulation obtained with this technology showed a broad-spectrum antimicrobial activity and anti-inflammatory and immunomodulatory properties based on multiple laboratory analyses. 11 Therefore, a major advance has been the development of a patented technology (Microcyn ® technology) in which a single, free, chlorine stream is generated without a by-product of sodium hydroxide (NaOH). Notably, the presence of various organic compounds and inorganic ions result in rapid consumption of HOCl by oxidation reactions. The reaction between H 2O 2 and Cl − to generate HOCl is then catalysed by myeloperoxidase (MPO). Neutrophils convert O 2 to hydrogen peroxide (H 2O 2) using a mitochondrial membrane-bound enzyme (NADPH oxidase). Hypochlorous acid (HOCl) production during the oxidative burst process.
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